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The Science: How the Three Peptides Work Together Retatrutide: The Triple Agonist Retatrutide (LY3437943) is a novel triple agonist peptide that simultaneously activates GLP-1, GIP, and glucagon receptors a first-in-class mechanism among research peptides

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Large doses may trigger hormonal changes or alter skin bacteria, leading to pimples or worsening of existing acne

Parks, University of Kansas Medical Center Background: Advanced physiologic age is often associated with increased body mass, fat to lean body mass ratio, and hepatic triglycerides (TG), and this can promote metabolic perturbations characteristic of non-alcohol associated fatty liver disease (NAFLD)